SCHEMBL5746191

SCHEMBL5746191

COc1cc2c[c]cc3ccc4cccc1c4c32

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 2/20 0.41
RXRA P19793 1/20 0.41
PPARD Q03181 1/20 0.41
PPARA Q07869 1/20 0.41
CYP1A2 P05177 3/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
MAPT P10636 2/20 0.40
NPC1 O15118 1/20 0.40
ERBB2 P04626 1/20 0.40
FYN P06241 1/20 0.40
MAOA P21397 1/20 0.40
ACHE P22303 1/20 0.40
AHR P35869 1/20 0.40
HPGD P15428 5/20 0.38
ALDH1A1 P00352 4/20 0.38
HSD17B10 Q99714 3/20 0.38
THRB P10828 1/20 0.38
CDK5 Q00535 1/20 0.38
CDK5R1 Q15078 1/20 0.38
CYP3A4 P08684 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5746707 0.90 SMN1; SMN2 (0.43) PPARGRXRAPPARDPPARACYP1A2
SCHEMBL16241709 0.86 CYP1A2 (0.52) PPARGRXRAPPARDPPARACYP1A2
SCHEMBL5747616 0.81 NQO1 (0.39) MAPTNPC1HPGDALDH1A1HSD17B10
SCHEMBL5749334 0.78 ALDH1A1 (0.55) CYP1A2MAPTERBB2FYNMAOA
SCHEMBL5748372 0.77 CYP1A2 (0.43) PPARGRXRAPPARDPPARACYP1A2
SCHEMBL2351815 0.75 HPGD (0.54) PPARGRXRAPPARDPPARACYP1A2
SCHEMBL5746447 0.74 IDO1 (0.47) PPARGRXRAPPARDPPARACYP1A2
SCHEMBL5745662 0.74 CYP1A2 (0.40) CYP1A2SMN1; SMN2MAPTERBB2FYN
SCHEMBL25424 0.74 ALDH1A1 (0.65) CYP1A2MAPTERBB2FYNMAOA
SCHEMBL5750455 0.74 PPARG (0.39) PPARGRXRAPPARDPPARACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060293503-A1 Polyaminopyridines and method for producing same SUMITOMO SEIKA CHEMICALS CO., LTD (JP) 2006-12-28 US disclosed
EP-1669390-A1 POLYAMINOPYRIDINES AND METHOD FOR PRODUCING SAME SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 2006-06-14 EP disclosed