SCHEMBL5746405

SCHEMBL5746405

COc1ccc2cc3cccc(N)c3cc2c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.55
CYP2A6 P11509 1/20 0.55
NCF1 P14598 1/20 0.45
ALDH1A1 P00352 3/20 0.44
CYP3A4 P08684 3/20 0.44
RAB9A P51151 1/20 0.44
MTNR1A P48039 3/20 0.43
GAA P10253 1/20 0.42
RCE1 Q9Y256 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
MEN1 O00255 1/20 0.42
MAPT P10636 1/20 0.42
THRB P10828 1/20 0.42
KMT2A Q03164 1/20 0.42
PARP1 P09874 1/20 0.41
BACE1 P56817 1/20 0.41
F2 P00734 1/20 0.41
PLG P00747 1/20 0.41
PLAU P00749 1/20 0.41
PLAT P00750 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5747140 1.00 CYP1A2 (0.55) CYP1A2CYP2A6NCF1ALDH1A1CYP3A4
SCHEMBL249717 0.87 CYP1A2 (0.55) CYP1A2CYP2A6ALDH1A1CYP3A4MTNR1A
SCHEMBL29792825 0.87 CYP1A2 (0.55) CYP1A2CYP2A6ALDH1A1CYP3A4MTNR1A
SCHEMBL30881789 0.87 CYP1A2 (0.55) CYP1A2CYP2A6NCF1ALDH1A1CYP3A4
SCHEMBL1806698 0.87 CYP1A2 (0.55) CYP1A2CYP2A6NCF1ALDH1A1CYP3A4
Hydrochloric Acid SCHEMBL10993696 0.86 CYP1A2 (0.53) CYP1A2CYP2A6ALDH1A1CYP3A4MTNR1A
Ethane SCHEMBL12612037 0.86 CYP1A2 (0.53) CYP1A2CYP2A6ALDH1A1CYP3A4MTNR1A
Hydrochloric Acid SCHEMBL9640549 0.86 CYP1A2 (0.53) CYP1A2CYP2A6NCF1ALDH1A1CYP3A4
SCHEMBL5008737 0.81 ALDH1A1 (0.54) CYP1A2ALDH1A1CYP3A4RAB9AGAA
SCHEMBL5012440 0.81 ALDH1A1 (0.54) CYP1A2ALDH1A1CYP3A4RAB9AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060293503-A1 Polyaminopyridines and method for producing same SUMITOMO SEIKA CHEMICALS CO., LTD (JP) 2006-12-28 US disclosed
EP-1669390-A1 POLYAMINOPYRIDINES AND METHOD FOR PRODUCING SAME SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 2006-06-14 EP disclosed