Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 7/20 | 0.68 |
| ▸ | ESR1 | P03372 | 7/20 | 0.68 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.68 |
| ▸ | TOP1 | P11387 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | AURKA | O14965 | 4/20 | 0.40 |
| ▸ | CDK1 | P06493 | 4/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.40 |
| ▸ | HPSE | Q9Y251 | 3/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746730 | 1.00 | HRAS (0.68) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL5748174 | 0.87 | TOP1 (0.62) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL14002822 | 0.87 | TOP1 (0.62) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL5749627 | 0.87 | TOP1 (0.62) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL5745871 | 0.87 | TOP1 (0.62) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL5746633 | 0.86 | HRAS (0.65) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL5746729 | 0.86 | HRAS (0.65) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7125320 | 0.83 | HRAS (0.83) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL23627239 | 0.82 | HRAS (0.48) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL25857874 | 0.82 | HRAS (0.48) | HRASESR1ESR2TOP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020446-B1 | NAPHTHALIMIDOBENZAMIDE DERIVATIVES | TAIHO PHARMACEUTICAL CO LTD (JP) | 2006-03-15 | — | — | EP | disclosed |
| US-6300331-B1 | DRUGS AS ANTITUMOR AGENTS OR ANTICARCINOGENIC AGENTS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-09 | — | — | US | disclosed |
| EP-1020446-A1 | NAPHTHALIMIDOBENZAMIDE DERIVATIVES | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |