Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.62 |
| ▸ | HRAS | P01112 | 1/20 | 0.62 |
| ▸ | ESR1 | P03372 | 1/20 | 0.62 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | HPSE | Q9Y251 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 3/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5749627 | 1.00 | TOP1 (0.62) | TOP1HRASESR1ESR2POLB | |
| SCHEMBL4855585 | 0.91 | HRAS (0.50) | TOP1HRASESR1ESR2POLB | |
| SCHEMBL5748174 | 0.88 | TOP1 (0.62) | TOP1HRASESR1ESR2POLB | |
| SCHEMBL14002822 | 0.88 | TOP1 (0.62) | TOP1HRASESR1ESR2POLB | |
| SCHEMBL5746730 | 0.87 | HRAS (0.68) | TOP1HRASESR1ESR2POLB | |
| SCHEMBL5746729 | 0.87 | HRAS (0.65) | TOP1HRASESR1ESR2POLB | |
| SCHEMBL5746639 | 0.87 | HRAS (0.68) | TOP1HRASESR1ESR2POLB | |
| SCHEMBL5746633 | 0.87 | HRAS (0.65) | TOP1HRASESR1ESR2POLB | |
| SCHEMBL14535121 | 0.84 | TOP1 (0.45) | TOP1HRASESR1ESR2POLB | |
| SCHEMBL14181025 | 0.83 | TOP1 (0.44) | TOP1HRASESR1ESR2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350145-B1 | DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL | UNIV TEXAS (US) | 2020-09-16 | — | — | EP | disclosed |
| US-10358439-B2 | DNA binding agents with a minor groove binding tail | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-07-23 | — | — | US | disclosed |
| US-10358439-B2 | DNA binding agents with a minor groove binding tail | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-07-23 | — | — | US | disclosed |
| US-20180251454-A1 | DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-09-06 | — | — | US | disclosed |
| WO-2017049091-A1 | DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-03-23 | — | — | WO | disclosed |
| EP-1020446-B1 | NAPHTHALIMIDOBENZAMIDE DERIVATIVES | TAIHO PHARMACEUTICAL CO LTD (JP) | 2006-03-15 | — | — | EP | disclosed |
| US-6300331-B1 | DRUGS AS ANTITUMOR AGENTS OR ANTICARCINOGENIC AGENTS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-09 | — | — | US | disclosed |
| EP-1020446-A1 | NAPHTHALIMIDOBENZAMIDE DERIVATIVES | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10358439-B2 | DNA binding agents with a minor groove binding tail | TOP2B, TOP2A, TOP1 | TOP1 3/4885HRAS 987/4885ESR1 4452/4885 |
| US-20180251454-A1 | DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL | TOP2B, TOP2A, TOP1 | TOP1 3/4885HRAS 987/4885ESR1 4452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.