SCHEMBL5747013

SCHEMBL5747013

O=c1c2ccccc2[nH]c2cccc(OCCCN3CCC3)c12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 1/20 0.54
CHRNB2 P17787 1/20 0.54
ACHE P22303 1/20 0.54
CHRNA7 P36544 1/20 0.54
CHRNA4 P43681 1/20 0.54
ABCG2 Q9UNQ0 1/20 0.53
TDP1 Q9NUW8 1/20 0.50
HRH3 Q9Y5N1 5/20 0.48
HTR2A P28223 2/20 0.48
HTR7 P34969 2/20 0.48
HTR6 P50406 2/20 0.48
CYP2D6 P10635 2/20 0.47
CYP2C19 P33261 2/20 0.47
ALDH1A1 P00352 5/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
ADRB2 P07550 1/20 0.44
L3MBTL1 Q9Y468 4/20 0.44
DRD3 P35462 2/20 0.44
KDM4E B2RXH2 2/20 0.44
HTT P42858 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5747882 0.94 ABCG2 (0.54) BCHECHRNB2ACHECHRNA7CHRNA4
SCHEMBL5747157 0.92 ABCG2 (0.54) BCHECHRNB2ACHECHRNA7CHRNA4
SCHEMBL5747873 0.91 ABCG2 (0.53) BCHECHRNB2ACHECHRNA7CHRNA4
SCHEMBL5748430 0.86 BCHE (0.52) BCHECHRNB2ACHECHRNA7CHRNA4
SCHEMBL5746363 0.83 TDP1 (0.53) BCHECHRNB2ACHECHRNA7CHRNA4
SCHEMBL5774079 0.82 HRH3 (0.53) BCHECHRNB2ACHECHRNA7CHRNA4
SCHEMBL5746509 0.80 TDP1 (0.54) BCHECHRNB2ACHECHRNA7CHRNA4
SCHEMBL5747923 0.80 ABCG2 (0.61) BCHECHRNB2ACHECHRNA7CHRNA4
SCHEMBL5748110 0.80 BCHE (0.47) BCHECHRNB2ACHECHRNA7CHRNA4
SCHEMBL5745434 0.79 CYP2D6 (0.50) TDP1HRH3HTR2AHTR7HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1711463-A2 AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE ABBOTT LABORATORIES (US) 2006-10-18 EP disclosed
WO-2005077899-A2 AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE ABBOTT LABORATORIES (US) 2005-08-25 WO disclosed