SCHEMBL5747157

SCHEMBL5747157

O=c1c2ccccc2[nH]c2cccc(OCCN3CCCC3)c12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 1/20 0.54
BCHE P06276 1/20 0.50
CHRNB2 P17787 1/20 0.50
ACHE P22303 1/20 0.50
CHRNA7 P36544 1/20 0.50
CHRNA4 P43681 1/20 0.50
TDP1 Q9NUW8 2/20 0.49
TSHR P16473 1/20 0.48
HRH3 Q9Y5N1 4/20 0.46
HTR2A P28223 2/20 0.46
HTR7 P34969 2/20 0.46
HTR6 P50406 2/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C19 P33261 1/20 0.46
HSD17B10 Q99714 1/20 0.46
DRD1 P21728 2/20 0.45
DRD3 P35462 2/20 0.45
DRD2 P14416 1/20 0.45
KDM4E B2RXH2 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5747873 0.99 ABCG2 (0.53) ABCG2BCHECHRNB2ACHECHRNA7
SCHEMBL5747882 0.98 ABCG2 (0.54) ABCG2BCHECHRNB2ACHECHRNA7
SCHEMBL5747013 0.92 BCHE (0.54) ABCG2BCHECHRNB2ACHECHRNA7
SCHEMBL5746101 0.85 TDP1 (0.49) BCHECHRNB2ACHECHRNA7CHRNA4
SCHEMBL5748212 0.84 TSHR (0.50) BCHECHRNB2ACHECHRNA7CHRNA4
SCHEMBL5748110 0.83 BCHE (0.47) BCHECHRNB2ACHECHRNA7CHRNA4
SCHEMBL5746976 0.80 TDP1 (0.54) TDP1TSHRHRH3HTR2AHTR7
SCHEMBL5746363 0.80 TDP1 (0.53) BCHECHRNB2ACHECHRNA7CHRNA4
SCHEMBL5748656 0.79 XDH (0.58) BCHEACHETDP1TSHRHRH3
SCHEMBL5774079 0.79 HRH3 (0.53) BCHECHRNB2ACHECHRNA7CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1711463-A2 AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE ABBOTT LABORATORIES (US) 2006-10-18 EP claimed
WO-2005077899-A2 AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE ABBOTT LABORATORIES (US) 2005-08-25 WO claimed
EP-1711463-A2 AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE ABBOTT LABORATORIES (US) 2006-10-18 EP disclosed
WO-2005077899-A2 AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE ABBOTT LABORATORIES (US) 2005-08-25 WO disclosed