Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747156 | 1.00 | HTT (0.52) | HTTGAASMN1; SMN2NPSR1MAPT | |
| SCHEMBL5747163 | 1.00 | HTT (0.52) | HTTGAASMN1; SMN2NPSR1MAPT | |
| SCHEMBL5745404 | 0.89 | PTGS2 (0.53) | HTTGAANPSR1MAPTL3MBTL1 | |
| SCHEMBL5747229 | 0.78 | KMT2A (0.53) | HTTGAANPSR1MAPTL3MBTL1 | |
| SCHEMBL9668771 | 0.74 | CCR1 (0.40) | NPSR1LMNAMEN1KMT2AMDM2 | |
| SCHEMBL5156506 | 0.71 | CACNA1B (0.61) | GAASMN1; SMN2NPSR1HPGDATM | |
| SCHEMBL22737743 | 0.68 | PTGS2 (0.54) | NPSR1KCNA5MEN1KMT2AHTR7 | |
| SCHEMBL26292080 | 0.66 | POLB (0.40) | GAASMN1; SMN2NPSR1KMT2A | |
| SCHEMBL9104273 | 0.65 | NPSR1 (0.43) | SMN1; SMN2NPSR1MAPTLMNAATM | |
| SCHEMBL21009001 | 0.65 | MDM2 (0.50) | HTTGAASMN1; SMN2NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173427-B1 | HYDROXAMIC ACID DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO (JP) | 2006-04-05 | — | — | EP | disclosed |
| US-6713477-B1 | 1,4-BENZTHIAZINES OR BENZOXAZINES; MATRIX METALLOPROTEINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-30 | — | — | US | disclosed |