Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049559 | 0.97 | PDE4B (0.44) | PDE4BMAPTKDM4EALDH1A1GAA | |
| SCHEMBL4051201 | 0.93 | PDE4B (0.44) | PDE4BCYP11B1CYP11B2IDO1JAK2 | |
| SCHEMBL4052611 | 0.87 | PDE4B (0.55) | PDE4BMAPTKDM4EALDH1A1POLB | |
| SCHEMBL4050693 | 0.86 | PDE4B (0.43) | PDE4BCYP11B1CYP11B2MAPTKDM4E | |
| SCHEMBL5753107 | 0.85 | PDE4B (0.39) | PDE4BCYP11B1CYP11B2ADORA2BADORA1 | |
| SCHEMBL4054494 | 0.82 | PDE4B (0.56) | PDE4BMAPTKDM4EALDH1A1POLB | |
| SCHEMBL4708670 | 0.82 | PDE4B (0.63) | PDE4BMAPTKDM4EALDH1A1POLB | |
| SCHEMBL4050190 | 0.82 | PDE4B (0.39) | PDE4BJAK1KDM4EALDH1A1GAA | |
| SCHEMBL5782757 | 0.81 | PDE4B (0.41) | PDE4BCNR1MAPTALDH1A1POLB | |
| SCHEMBL4051111 | 0.81 | PDE4B (0.44) | PDE4BCYP11B1CYP11B2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682519-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005049581-A1 | PYRIDAZIN-3 (2H) -ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA, S.A. (ES) | 2005-06-02 | — | — | WO | disclosed |