Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.37 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 5/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050693 | 0.93 | PDE4B (0.43) | PDE4BCYP11B1CYP11B2CSNK1DCSNK1E | |
| SCHEMBL4057211 | 0.90 | ADORA1 (0.41) | PDE4BCYP11B1CYP11B2PIP4K2AADORA1 | |
| SCHEMBL4051111 | 0.90 | PDE4B (0.44) | PDE4BCYP11B1CYP11B2CSNK1DCSNK1E | |
| SCHEMBL5782757 | 0.88 | PDE4B (0.41) | PDE4BADORA1 | |
| SCHEMBL5747425 | 0.85 | PDE4B (0.42) | PDE4BCYP11B1CYP11B2CSNK1DCSNK1E | |
| SCHEMBL4049559 | 0.82 | PDE4B (0.44) | PDE4BPIP4K2AADORA1ADORA2B | |
| SCHEMBL4052611 | 0.82 | PDE4B (0.55) | PDE4BADORA1 | |
| SCHEMBL4050784 | 0.81 | PDE4B (0.48) | PDE4BADORA1ADORA2B | |
| SCHEMBL4050190 | 0.79 | PDE4B (0.39) | PDE4BPIP4K2AADORA1ADORA2B | |
| SCHEMBL4707445 | 0.79 | PDE4B (0.62) | PDE4BADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682519-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005049581-A1 | PYRIDAZIN-3 (2H) -ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA, S.A. (ES) | 2005-06-02 | — | — | WO | disclosed |