Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.49 |
| ▸ | ACACB | O00763 | 6/20 | 0.46 |
| ▸ | ACACA | Q13085 | 6/20 | 0.46 |
| ▸ | CNR1 | P21554 | 4/20 | 0.44 |
| ▸ | CNR2 | P34972 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3837843 | 1.00 | P2RX7 (0.49) | P2RX7ACACBACACACNR1CNR2 | |
| SCHEMBL5747142 | 0.84 | P2RX7 (0.54) | P2RX7ACACBACACA | |
| SCHEMBL1805331 | 0.84 | P2RX7 (0.69) | P2RX7 | |
| SCHEMBL1805240 | 0.84 | P2RX7 (0.69) | P2RX7 | |
| SCHEMBL1804304 | 0.84 | P2RX7 (0.54) | P2RX7ACACBACACA | |
| SCHEMBL5767624 | 0.84 | P2RX7 (0.69) | P2RX7 | |
| Hydrochloric Acid SCHEMBL3842335 | 0.83 | P2RX7 (0.68) | P2RX7 | |
| SCHEMBL5745880 | 0.79 | P2RX7 (0.67) | P2RX7 | |
| SCHEMBL1803780 | 0.79 | P2RX7 (0.67) | P2RX7 | |
| SCHEMBL3837020 | 0.78 | P2RX7 (0.65) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633717-A1 | NEW P2X7 RECEPTOR ANTAGONISTS AND THEIR USE | AstraZeneca AB (SE) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004106305-A1 | NEW P2X7 RECEPTOR ANTAGONISTS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-12-09 | — | — | WO | disclosed |