Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.37 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL575024 | 0.63 | CYP4F2 (0.39) | — | |
| SCHEMBL574453 | 0.63 | PTGES2 (0.54) | BRAFCYP3A4CYP2C9POLBKMT2A | |
| SCHEMBL15191648 | 0.61 | BRAF (0.46) | BRAFNR1I2EIF2AK3PIK3CAPIK3R1 | |
| SCHEMBL15192731 | 0.60 | BRAF (0.44) | BRAFNR1I2EIF2AK3PIK3CAPIK3R1 | |
| SCHEMBL29721254 | 0.60 | CYP3A4 (0.52) | BRAFCYP3A4CYP2C9 | |
| SCHEMBL29721313 | 0.60 | CYP3A4 (0.52) | BRAFCYP3A4CYP2C9 | |
| SCHEMBL1127184 | 0.60 | CYP3A4 (0.52) | BRAFCYP3A4CYP2C9 | |
| SCHEMBL574829 | 0.59 | BRAF (0.44) | BRAFNR1I2EIF2AK3PIK3CA | |
| SCHEMBL574840 | 0.59 | CYP4F2 (0.39) | — | |
| SCHEMBL1818665 | 0.59 | PTGES2 (0.48) | BRAFCYP3A4CYP2C9POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601185-A1 | DERIVATIVES OF PYRAZOLOPHENYL-BENZENESULFONAMIDE COMPOUNDS AND USE THEREOF AS ANTITUMOR AGENTS | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012016993-A1 | DERIVATIVES OF PYRAZOLOPHENYL-BENZENESULFONAMIDE COMPOUNDS AND USE THEREOF AS ANTITUMOR AGENTS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-09 | — | — | WO | disclosed |