Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.39 |
| ▸ | ATR | Q13535 | 14/20 | 0.39 |
| ▸ | ALPL | P05186 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL574795 | 0.82 | BRAF (0.39) | ATRHTR1ADRD2HTR7HTR6 | |
| SCHEMBL574840 | 0.77 | CYP4F2 (0.39) | CYP4F2CYP4A11ATR | |
| SCHEMBL575020 | 0.69 | KDM1A (0.37) | HTR1ADRD2HTR7HTR6 | |
| SCHEMBL574922 | 0.68 | CYP4F2 (0.43) | CYP4F2CYP4A11ATR | |
| SCHEMBL22153397 | 0.67 | ATR (0.40) | CYP4F2CYP4A11ATR | |
| SCHEMBL18536634 | 0.66 | ATR (0.55) | CYP4F2CYP4A11ATR | |
| SCHEMBL574770 | 0.63 | BRAF (0.37) | — | |
| SCHEMBL15509064 | 0.62 | CYP4F2 (0.47) | CYP4F2CYP4A11ATR | |
| SCHEMBL23535790 | 0.62 | CYP4F2 (0.50) | CYP4F2CYP4A11ATR | |
| SCHEMBL24693881 | 0.62 | CYP4F2 (0.50) | CYP4F2CYP4A11ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601185-A1 | DERIVATIVES OF PYRAZOLOPHENYL-BENZENESULFONAMIDE COMPOUNDS AND USE THEREOF AS ANTITUMOR AGENTS | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012016993-A1 | DERIVATIVES OF PYRAZOLOPHENYL-BENZENESULFONAMIDE COMPOUNDS AND USE THEREOF AS ANTITUMOR AGENTS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-09 | — | — | WO | disclosed |