SCHEMBL5747739

SCHEMBL5747739

COc1cc2cccc3ccc4cc(N)cc1c4c32

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.41
ERBB2 P04626 1/20 0.41
FYN P06241 1/20 0.41
MAOA P21397 1/20 0.41
ACHE P22303 1/20 0.41
AHR P35869 1/20 0.41
NPC1 O15118 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
TLR8 Q9NR97 1/20 0.40
MCHR1 Q99705 1/20 0.40
PPARG P37231 2/20 0.39
RXRA P19793 1/20 0.39
PPARD Q03181 1/20 0.39
PPARA Q07869 1/20 0.39
CDK5 Q00535 1/20 0.39
CDK5R1 Q15078 1/20 0.39
ALDH1A1 P00352 3/20 0.39
CYP3A4 P08684 3/20 0.39
HSD17B10 Q99714 3/20 0.39
TDP1 Q9NUW8 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5748372 0.92 CYP1A2 (0.43) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL16241709 0.84 CYP1A2 (0.52) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL5749206 0.81 CYP1A2 (0.46) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL5746862 0.81 NQO1 (0.42) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL5748942 0.79 IDO1 (0.43) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL5746447 0.79 IDO1 (0.47) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL5574510 0.78 CYP3A4 (0.61) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL5747755 0.77 ALDH1A1 (0.52) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL5745785 0.76 NPC1 (0.42) CYP1A2NPC1SMN1; SMN2TLR8MCHR1
SCHEMBL27869644 0.76 NPC1 (0.54) CYP1A2ERBB2FYNMAOAACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060293503-A1 Polyaminopyridines and method for producing same SUMITOMO SEIKA CHEMICALS CO., LTD (JP) 2006-12-28 US disclosed
EP-1669390-A1 POLYAMINOPYRIDINES AND METHOD FOR PRODUCING SAME SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 2006-06-14 EP disclosed