Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.60 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.60 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.60 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27984882 | 0.79 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11BRD4 | |
| SCHEMBL11417661 | 0.77 | NPC1 (0.46) | MAPK14MAPK13MAPK12MAPK11NSD3 | |
| SCHEMBL4910253 | 0.76 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11TGFBR1 | |
| SCHEMBL1639811 | 0.74 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11BRD4 | |
| SCHEMBL5574792 | 0.74 | NSD3 (0.55) | NSD3PTGS2TSHRCSNK1DLMNA | |
| SCHEMBL16986283 | 0.73 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11NSD3 | |
| SCHEMBL1640842 | 0.72 | MAPK14 (0.80) | MAPK14MAPK13MAPK12MAPK11BRD4 | |
| SCHEMBL19864314 | 0.72 | MAPK14 (0.90) | MAPK14MAPK13MAPK12MAPK11TGFBR1 | |
| SCHEMBL9842956 | 0.71 | NSD3 (0.51) | NSD3PTGS2TSHRCSNK1DLMNA | |
| SCHEMBL1009513 | 0.71 | NSD3 (0.83) | MAPK14NSD3PTGS2TSHRTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537112-B1 | CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |
| EP-1537112-A1 | CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | Astrazeneca AB (SE) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004013141-A1 | CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-12 | — | — | WO | disclosed |