Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3202566 | 0.78 | GSK3B (0.49) | GSK3BLMNANAPRTP4HTML3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL27586292 | 0.74 | L3MBTL1 (0.47) | LMNANAPRTP4HTML3MBTL1SMN1; SMN2 | |
| SCHEMBL5746725 | 0.72 | GSK3B (0.46) | GSK3BLMNANAPRTP4HTML3MBTL1 | |
| SCHEMBL32662174 | 0.70 | CYP1A2 (0.46) | SMN1; SMN2ALDH1A1KDM4ETDP1MAPT | |
| SCHEMBL6312924 | 0.70 | ATM (0.43) | LMNAL3MBTL1NPC1RAB9AALDH1A1 | |
| SCHEMBL24443482 | 0.69 | NPC1 (0.42) | LMNANAPRTP4HTML3MBTL1SMN1; SMN2 | |
| SCHEMBL29689910 | 0.69 | NPC1 (0.42) | LMNANAPRTP4HTML3MBTL1SMN1; SMN2 | |
| SCHEMBL10957821 | 0.69 | ATM (0.42) | LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL10957808 | 0.69 | ATM (0.42) | LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL23099848 | 0.69 | ATM (0.42) | LMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636218-A1 | THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GmbH (DE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2005003128-A1 | THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GMBH (DE) | 2005-01-13 | — | — | WO | disclosed |