Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 17/20 | 0.51 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3843919 | 0.87 | P2RX7 (0.52) | P2RX7KCNQ3KCNQ2L3MBTL1 | |
| SCHEMBL3841342 | 0.87 | P2RX7 (0.52) | P2RX7KCNQ3KCNQ2L3MBTL1 | |
| SCHEMBL1804218 | 0.84 | P2RX7 (0.68) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL5744327 | 0.84 | P2RX7 (0.68) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL1805634 | 0.84 | P2RX7 (0.68) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL3837025 | 0.84 | P2RX7 (0.54) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL1804098 | 0.84 | P2RX7 (0.54) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL3837101 | 0.83 | P2RX7 (0.56) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL1804722 | 0.83 | P2RX7 (0.56) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL3836983 | 0.83 | P2RX7 (0.50) | P2RX7KCNQ3KCNQ2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633717-A1 | NEW P2X7 RECEPTOR ANTAGONISTS AND THEIR USE | AstraZeneca AB (SE) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004106305-A1 | NEW P2X7 RECEPTOR ANTAGONISTS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-12-09 | — | — | WO | disclosed |