SCHEMBL5748718

SCHEMBL5748718

Nc1cc2ccc3cc(C=O)cc4ccc(c1)c2c34

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 7/20 0.35
TYMS P04818 1/20 0.35
ALDH1A1 P00352 6/20 0.34
CYP3A4 P08684 2/20 0.34
HSD17B10 Q99714 2/20 0.34
MPO P05164 1/20 0.34
ALOX15 P16050 1/20 0.33
CASP1 P29466 1/20 0.33
CASP7 P55210 1/20 0.33
HBB P68871 1/20 0.33
HIF1A Q16665 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
KDM4E B2RXH2 2/20 0.32
CYP19A1 P11511 1/20 0.32
MEN1 O00255 1/20 0.32
MAPT P10636 1/20 0.32
KMT2A Q03164 1/20 0.32
PTGS2 P35354 1/20 0.32
RAB9A P51151 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9797581 0.88 CYP2A6 (0.41) CYP2A6ALDH1A1HSD17B10KDM4EPTGS2
SCHEMBL2820496 0.80 CYP3A4 (0.48) TYMSALDH1A1CYP3A4HSD17B10MPO
SCHEMBL31040467 0.80 CYP3A4 (0.48) TYMSALDH1A1CYP3A4HSD17B10MPO
SCHEMBL3735918 0.79 ALDH1A1 (0.52) CYP2A6ALDH1A1CYP3A4HSD17B10TDP1
SCHEMBL29590945 0.79 ALDH1A1 (0.52) CYP2A6ALDH1A1CYP3A4HSD17B10TDP1
SCHEMBL5748274 0.78 ERBB2 (0.36) CYP2A6ALDH1A1CYP3A4HSD17B10TDP1
SCHEMBL29957342 0.77 ALDH1A1 (0.50) CYP2A6ALDH1A1CYP3A4HSD17B10ALOX15
SCHEMBL2346924 0.77 ALDH1A1 (0.50) CYP2A6ALDH1A1CYP3A4HSD17B10ALOX15
SCHEMBL9099739 0.76 ALDH1A1 (0.48) CYP2A6ALDH1A1CYP3A4HSD17B10ALOX15
SCHEMBL29954379 0.76 ALDH1A1 (0.48) CYP2A6ALDH1A1CYP3A4HSD17B10ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060293503-A1 Polyaminopyridines and method for producing same SUMITOMO SEIKA CHEMICALS CO., LTD (JP) 2006-12-28 US disclosed
EP-1669390-A1 POLYAMINOPYRIDINES AND METHOD FOR PRODUCING SAME SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 2006-06-14 EP disclosed