Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | HTR2B | P41595 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747101 | 0.99 | TDP1 (0.52) | TDP1HTR2AHTR2CHTR2BTSHR | |
| SCHEMBL5774116 | 0.94 | HRH3 (0.53) | TDP1HTR2AHRH3HTR7HTR6 | |
| SCHEMBL5745434 | 0.91 | CYP2D6 (0.50) | TDP1HTR2AHRH3HTR7HTR6 | |
| SCHEMBL5772672 | 0.86 | HTR2A (0.50) | TDP1HTR2AHTR2CHTR2BTSHR | |
| SCHEMBL5745919 | 0.86 | TDP1 (0.51) | TDP1HTR2AHTR2CHTR2BTSHR | |
| SCHEMBL11376119 | 0.86 | TDP1 (0.51) | TDP1HTR2AHTR2CHTR2BTSHR | |
| SCHEMBL5749114 | 0.84 | TDP1 (0.52) | TDP1HTR2AHTR2CHTR2BTSHR | |
| SCHEMBL11382220 | 0.84 | TDP1 (0.52) | TDP1HTR2AHTR2CHTR2BTSHR | |
| SCHEMBL5777884 | 0.83 | KDM1A (0.48) | TDP1HTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL5749436 | 0.82 | TDP1 (0.49) | TDP1HTR2AHTR2CHTR2BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | disclosed |
| US-4244954-A | Acridine compounds and methods of combatting viruses with them | STERLING DRUG INC. (US) | 1981-01-13 | — | — | US | disclosed |