Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.50 |
| ▸ | HTR2C | P28335 | 4/20 | 0.50 |
| ▸ | HTR2B | P41595 | 4/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777884 | 0.97 | KDM1A (0.48) | HTR2AHTR2CHTR2BKDM1AMAPT | |
| SCHEMBL5770520 | 0.91 | KDM1A (0.47) | HTR2AHTR2CHTR2BKDM1AMAPT | |
| SCHEMBL5749161 | 0.86 | TDP1 (0.51) | HTR2AHTR2CHTR2BMAPTHTT | |
| SCHEMBL5747101 | 0.85 | TDP1 (0.52) | HTR2AHTR2CHTR2BMAPTHTT | |
| SCHEMBL5776994 | 0.83 | HTT (0.52) | KDM1AMAPTHTTMEN1GAA | |
| SCHEMBL5773781 | 0.81 | HTT (0.50) | KDM1AMAPTHTTMEN1GAA | |
| SCHEMBL5774116 | 0.81 | HRH3 (0.53) | HTR2AMAPTMEN1KMT2ATDP1 | |
| SCHEMBL5772233 | 0.80 | KDM1A (0.49) | KDM1AMAPTHTTGAAKMT2A | |
| SCHEMBL5775529 | 0.80 | KDM1A (0.49) | KDM1AMAPTHTTGAAKMT2A | |
| SCHEMBL5772950 | 0.79 | G6PD (0.49) | KDM1AMAPTHTTGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |