Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5749076 | 0.92 | HCRTR1 (0.48) | HCRTR1HCRTR2HSD11B1SLC6A9KCNH2 | |
| SCHEMBL5745087 | 0.89 | HCRTR1 (0.45) | HCRTR1HCRTR2HSD11B1SLC6A9KCNH2 | |
| SCHEMBL5771120 | 0.89 | CHRM2 (0.41) | HCRTR1HCRTR2HSD11B1CHRM2CHRM1 | |
| SCHEMBL6349104 | 0.89 | HSD11B1 (0.46) | HCRTR1HCRTR2HSD11B1HPGDSMN1; SMN2 | |
| SCHEMBL5749138 | 0.89 | HSD11B1 (0.46) | HCRTR1HCRTR2HSD11B1HPGDSMN1; SMN2 | |
| SCHEMBL5747362 | 0.85 | KDM4E (0.56) | HCRTR1HCRTR2SLC6A9KCNH2SLC6A5 | |
| SCHEMBL5796696 | 0.85 | HCRTR1 (0.54) | HCRTR1HCRTR2HSD11B1HPGDSMN1; SMN2 | |
| SCHEMBL5800472 | 0.83 | HSD11B1 (0.44) | HCRTR1HCRTR2HSD11B1HPGDSMN1; SMN2 | |
| SCHEMBL5774048 | 0.83 | HSD11B1 (0.45) | HCRTR1HCRTR2HSD11B1HPGDSMN1; SMN2 | |
| SCHEMBL1470481 | 0.83 | HSD11B1 (0.42) | HCRTR1HCRTR2HSD11B1GPR119KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735280-A1 | ARYL SULFONAMIDE AND SULFONYL COMPOUNDS AS MODULATORS OF PPAR AND METHODS OF TREATING METABOLIC DISORDERS | Kalypsys, Inc. (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005115983-A1 | ARYL SULFONAMIDE AND SULFONYL COMPOUNDS AS MODULATORS OF PPAR AND METHODS OF TREATING METABOLIC DISORDERS | KALYPSYS, INC. (US) | 2005-12-08 | — | — | WO | disclosed |
| US-20050234046-A1 | Aryl sulfonamide and sulfonyl compounds as modulators of PPAR and methods of treating metabolic disorders | KALYPSYS, INC. (US) | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234046-A1 | Aryl sulfonamide and sulfonyl compounds as modulators of PPAR and methods of treating metabolic disorders | PPARA, PPARG, PPARD | HCRTR1 1605/4885HCRTR2 1317/4885HSD11B1 668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.