Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARBP2 | Q15633 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4679820 | 0.86 | TARBP2 (0.55) | TARBP2MAPTTRPM8GABRA2GABRB2 | |
| SCHEMBL4680986 | 0.85 | CDH1 (0.43) | DHODHALDH1A1LMNACYP1A2CYP2C9 | |
| SCHEMBL4677506 | 0.83 | TARBP2 (0.52) | TARBP2MAPTTRPM8GABRA2GABRB2 | |
| SCHEMBL4680694 | 0.83 | TARBP2 (0.52) | TARBP2MAPTTRPM8GABRA2GABRB2 | |
| SCHEMBL5755581 | 0.81 | TARBP2 (0.50) | TARBP2MAPTTRPM8GABRA2GABRB2 | |
| SCHEMBL4680961 | 0.79 | TARBP2 (0.58) | TARBP2MAPTTRPM8GABRA2GABRB2 | |
| SCHEMBL4680740 | 0.77 | SMN1; SMN2 (0.47) | MAPTDHODHALDH1A1LMNACNR1 | |
| SCHEMBL4681325 | 0.77 | TARBP2 (0.53) | TARBP2MAPTTRPM8GABRA2GABRB2 | |
| SCHEMBL4681469 | 0.76 | CDH1 (0.48) | DHODHALDH1A1LMNACYP1A2CYP2C9 | |
| SCHEMBL5751178 | 0.76 | TARBP2 (0.47) | TARBP2MAPTTRPM8GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638953-A1 | 3-SUBSTITUTED 5,6-DIARYL-PYRAZINE-2-CARBOXAMIDE AND -2-SULFONAMIDE DERIVATIVES AS CB1 MODULATORS | AstraZeneca AB (SE) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004111034-A1 | 3-SUBSTITUTED 5,6-DIARYL-PYRAZINE-2-CARBOXAMIDE AND -2-SULFONAMIDE DERIVATIVES AS CB1 MODULATORS | ASTRAZENECA AB (SE) | 2004-12-23 | — | — | WO | disclosed |