Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 18/20 | 0.54 |
| ▸ | PDE7B | Q9NP56 | 4/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5751276 | 0.85 | SMPD3 (0.42) | PDE7APDE7BSMPD3 | |
| SCHEMBL5232537 | 0.83 | PDE7A (0.68) | PDE7APDE7BPDE4D | |
| SCHEMBL1813868 | 0.79 | PDE7A (0.57) | PDE7APDE7BPDE4D | |
| SCHEMBL5232033 | 0.73 | PDE7A (0.72) | PDE7APDE7BPDE4D | |
| SCHEMBL5236072 | 0.73 | PDE7A (0.72) | PDE7APDE7BPDE4D | |
| SCHEMBL5230528 | 0.72 | PDE7A (0.68) | PDE7APDE7BPDE4D | |
| SCHEMBL5228274 | 0.72 | PDE7A (0.53) | PDE7APDE7B | |
| SCHEMBL5230898 | 0.72 | PDE7A (0.62) | PDE7APDE7BPDE4D | |
| SCHEMBL5234070 | 0.72 | PDE7A (0.64) | PDE7APDE7BPDE4D | |
| SCHEMBL5232790 | 0.71 | PDE7A (0.69) | PDE7APDE7BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636235-A1 | PYRIDINYLPYRAZOLOPYRIMIDINONE DERIVATIVES AS PDE 7 INHIBITORS | Daiichi Asubio Pharma Co., Ltd. (JP) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004111054-A1 | PYRIDINYLPYRAZOLOPYRIMIDINONE DERIVATIVES AS PDE 7 INHIBITORS | DAIICHI ASUBIO PHARMA CO.,LTD. (JP) | 2004-12-23 | — | — | WO | disclosed |