Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 9/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | SMPD2 | O60906 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5751271 | 0.85 | PDE7A (0.54) | SMPD3PDE7APDE7B | |
| SCHEMBL1813866 | 0.79 | CKS1B (0.40) | SMPD3CKS1BSKP1SKP2PDE7A | |
| SCHEMBL5236084 | 0.74 | PDE7A (0.51) | PDE7APDE7B | |
| SCHEMBL5234076 | 0.73 | PDE7A (0.49) | PDE7APDE7B | |
| SCHEMBL5230535 | 0.73 | PDE7A (0.48) | PDE7APDE7BMAPT | |
| SCHEMBL5232794 | 0.72 | PDE7A (0.49) | PDE7APDE7B | |
| SCHEMBL5230543 | 0.72 | PDE7A (0.62) | PDE7APDE7B | |
| SCHEMBL5230908 | 0.72 | PDE7A (0.44) | PDE7APDE7B | |
| SCHEMBL5230266 | 0.71 | PDE7A (0.47) | PDE7APDE7B | |
| SCHEMBL5232097 | 0.71 | PDE7A (0.63) | PDE7APDE7B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636235-A1 | PYRIDINYLPYRAZOLOPYRIMIDINONE DERIVATIVES AS PDE 7 INHIBITORS | Daiichi Asubio Pharma Co., Ltd. (JP) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004111054-A1 | PYRIDINYLPYRAZOLOPYRIMIDINONE DERIVATIVES AS PDE 7 INHIBITORS | DAIICHI ASUBIO PHARMA CO.,LTD. (JP) | 2004-12-23 | — | — | WO | disclosed |