SCHEMBL5751392

SCHEMBL5751392

NC(Cc1ccc(CC(F)(F)C(F)(F)F)cc1)C(O)c1cccc(Cl)c1

nearest known ligand 0.39

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 3/20 0.39
PNMT P11086 1/20 0.36
ADRB3 P13945 7/20 0.35
ADRB1 P08588 5/20 0.35
ADRB2 P07550 4/20 0.35
TACR1 P25103 2/20 0.34
ADRA1D P25100 1/20 0.33
ADRA1A P35348 1/20 0.33
ADRA1B P35368 1/20 0.33
AOC3 Q16853 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5754070 0.85 SLC2A1 (0.43) SLC2A1PNMTADRB3ADRB1ADRB2
SCHEMBL5751830 0.82 ADRB3 (0.42) SLC2A1ADRB3ADRB1ADRB2ADRA1D
SCHEMBL5753866 0.81 SLC2A1 (0.42) SLC2A1PNMTADRB3ADRB1ADRB2
SCHEMBL5753904 0.80 SLC2A1 (0.43) SLC2A1PNMTADRB3ADRB1ADRB2
SCHEMBL5753171 0.79 ADRB3 (0.40) SLC2A1ADRB3ADRB1ADRB2ADRA1D
SCHEMBL7157741 0.79 ADRB3 (0.40) SLC2A1ADRB3ADRB1ADRB2ADRA1D
SCHEMBL5752334 0.77 SLC2A1 (0.46) SLC2A1ADRB3ADRB1ADRB2ADRA1D
SCHEMBL5750724 0.77 SLC2A1 (0.40) SLC2A1PNMTADRB3ADRB1ADRB2
SCHEMBL5750415 0.74 CETP (0.44)
SCHEMBL5751748 0.73 PNMT (0.47) SLC2A1PNMTADRB1TACR1ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6982348-B2 Aminoethanol derivatives TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2006-01-03 US disclosed
US-20040127574-A1 Aminoethanol derivatives TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2004-07-01 US disclosed
EP-1362846-A1 AMINOETHANOL DERIVATIVES Takeda Chemical Industries, Ltd. (JP) 2003-11-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040127574-A1 Aminoethanol derivatives CETP, LCAT, MTTP SLC2A1 301/4885PNMT 172/4885ADRB3 85/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.