Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.53 |
| ▸ | CCND3 | P30281 | 15/20 | 0.53 |
| ▸ | CCND1 | P24385 | 14/20 | 0.53 |
| ▸ | CCND2 | P30279 | 11/20 | 0.53 |
| ▸ | CDK1 | P06493 | 6/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.46 |
| ▸ | CDK2 | P24941 | 11/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.45 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5749838 | 0.84 | CDK4 (0.50) | CDK4CCND3CCND1CCND2CDK1 | |
| SCHEMBL5750824 | 0.77 | CDK4 (0.55) | CDK4CCND3CCND1CCND2CDK1 | |
| SCHEMBL6942006 | 0.76 | CDK4 (0.56) | CDK4CCND3CCND1CCND2CDK1 | |
| SCHEMBL5750686 | 0.75 | CDK4 (0.46) | CDK4CCND3CCND1CCND2CDK1 | |
| SCHEMBL6387070 | 0.74 | CDK4 (0.59) | CDK4CCND3CCND1CCND2CDK1 | |
| SCHEMBL6390834 | 0.73 | CDK4 (0.82) | CDK4CCND3CCND1CCND2CDK1 | |
| SCHEMBL5753043 | 0.73 | CDK4 (0.61) | CDK4CCND3CCND1CCND2CDK1 | |
| SCHEMBL5753166 | 0.73 | CDK4 (0.57) | CDK4CCND3CCND1CCND2CDK1 | |
| SCHEMBL5750104 | 0.73 | CDK4 (0.82) | CDK4CCND3CCND1CCND2CDK1 | |
| SCHEMBL5749427 | 0.71 | CDK4 (0.81) | CDK4CCND3CCND1CCND2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050182078-A1 | 2-(Pyridin-3-ylamino)-pyrido[2,3-D]pyrimidin-7-ones | WARNER-LAMBERT COMPANY, LLC | 2005-08-18 | — | — | US | claimed |
| EP-1718645-A1 | 2-(PYRIDIN-3-YLAMINO)-PYRIDO 2,3-D PYRIMIDIN-7-ONES | Warner-Lambert Company LLC (US) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005082903-A1 | 2-(PYRIDIN-3-YLAMINO)-PYRIDO[2,3-D]PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY LLC (US) | 2005-09-09 | — | — | WO | disclosed |
| US-20050182078-A1 | 2-(Pyridin-3-ylamino)-pyrido[2,3-D]pyrimidin-7-ones | WARNER-LAMBERT COMPANY, LLC | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182078-A1 | 2-(Pyridin-3-ylamino)-pyrido[2,3-D]pyrimidin-7-ones | CDK2, CDK4, CDK1 | CDK4 2/4885CCND3 28/4885CCND1 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.