SCHEMBL6942006

SCHEMBL6942006

CCCn1c(=O)c(F)c(C)c2cnc(Nc3ccc(N4CCNCC4)c(Cl)c3)nc21

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 11/20 0.56
CCND1 P24385 10/20 0.56
CCND2 P30279 10/20 0.56
CCND3 P30281 10/20 0.56
PAK3 O75914 1/20 0.54
PAK4 O96013 1/20 0.54
LIMK1 P53667 1/20 0.54
LIMK2 P53671 1/20 0.54
PAK1 Q13153 1/20 0.54
PAK2 Q13177 1/20 0.54
PKN1 Q16512 1/20 0.54
KCNH2 Q12809 1/20 0.49
WEE1 P30291 4/20 0.48
CCNA2 P20248 5/20 0.47
CDK2 P24941 5/20 0.47
CCNA1 P78396 5/20 0.47
CCNE2 O96020 4/20 0.47
CCNE1 P24864 4/20 0.47
CCNB2 O95067 3/20 0.46
CDK1 P06493 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6940718 0.86 CDK4 (0.70) CDK4CCND1CCND2CCND3PAK3
SCHEMBL6941999 0.85 CDK4 (0.57) CDK4CCND1CCND2CCND3PAK3
SCHEMBL5751618 0.76 CDK4 (0.53) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL6939784 0.76 CDK4 (0.56) CDK4CCND1CCND2CCND3PAK4
SCHEMBL6942106 0.75 CDK4 (0.79) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL6938634 0.75 CDK4 (0.78) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL6940711 0.74 CDK4 (0.77) CDK4CCND1CCND2CCND3PAK3
SCHEMBL7077972 0.73 CDK4 (0.45) CDK4CCND1CCND2CCND3PAK3
SCHEMBL6945561 0.73 CDK4 (0.65) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL6939792 0.72 CDK4 (0.57) CDK4CCND1CCND2CCND3CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1268476-A1 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS WARNER-LAMBERT COMPANY (US) 2003-01-02 EP claimed
WO-2001070741-A1 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS WARNER-LAMBERT COMPANY (US) 2001-09-27 WO claimed
EP-1268476-A1 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS WARNER-LAMBERT COMPANY (US) 2003-01-02 EP disclosed
WO-2001070741-A1 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS WARNER-LAMBERT COMPANY (US) 2001-09-27 WO disclosed