Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4062339 | 0.78 | KCNH2 (0.44) | KCNH2 | |
| SCHEMBL5751526 | 0.77 | KCNH2 (0.42) | KCNH2PIK3CAMTOR | |
| SCHEMBL1224605 | 0.76 | SIGMAR1 (0.45) | KCNH2SLC2A1PIK3CAMTOR | |
| SCHEMBL5751874 | 0.75 | KCNH2 (0.39) | KCNH2 | |
| SCHEMBL632653 | 0.71 | PTPN11 (0.36) | KCNH2MTNR1AMTNR1BPTPN11 | |
| SCHEMBL5749909 | 0.70 | KCNH2 (0.57) | KCNH2 | |
| SCHEMBL5746863 | 0.69 | KCNH2 (0.44) | KCNH2 | |
| SCHEMBL5750585 | 0.67 | KCNH2 (0.49) | KCNH2SLC2A1 | |
| SCHEMBL5749905 | 0.67 | KCNH2 (0.49) | KCNH2SLC2A1 | |
| SCHEMBL5750027 | 0.67 | KCNH2 (0.48) | KCNH2SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1419155-B1 | PIPERIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2006-11-08 | — | — | EP | disclosed |
| EP-1419155-A2 | PIPERIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2004-05-19 | — | — | EP | disclosed |
| WO-2003010138-A2 | PIPERIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2003-02-06 | — | — | WO | disclosed |