Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | PPOX | P50336 | 1/20 | 0.48 |
| ▸ | PARG | Q86W56 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.42 |
| ▸ | RGS12 | O14924 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27454107 | 0.84 | ATG4B (0.52) | PARP1NPSR1MEN1KMT2APKM | |
| SCHEMBL2487811 | 0.80 | PARP1 (1.00) | PARP1NPSR1MEN1KMT2APKM | |
| SCHEMBL57038 | 0.80 | PARP1 (1.00) | PARP1NPSR1MEN1KMT2APKM | |
| SCHEMBL5051981 | 0.80 | PARP1 (0.62) | PARP1NPSR1MEN1KMT2APKM | |
| SCHEMBL31156926 | 0.79 | NPSR1 (1.00) | PARP1NPSR1MEN1KMT2APKM | |
| SCHEMBL5750580 | 0.79 | PARP1 (0.66) | PARP1NPSR1MEN1KMT2APKM | |
| SCHEMBL5749227 | 0.79 | NPSR1 (1.00) | PARP1NPSR1MEN1KMT2APKM | |
| SCHEMBL14463935 | 0.79 | PARP1 (0.66) | PARP1NPSR1MEN1KMT2APKM | |
| SCHEMBL1566195 | 0.79 | PARP1 (0.66) | PARP1NPSR1MEN1KMT2APKM | |
| SCHEMBL29255681 | 0.78 | PARP1 (0.95) | PARP1NPSR1MEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020446-B1 | NAPHTHALIMIDOBENZAMIDE DERIVATIVES | TAIHO PHARMACEUTICAL CO LTD (JP) | 2006-03-15 | — | — | EP | disclosed |
| US-6300331-B1 | DRUGS AS ANTITUMOR AGENTS OR ANTICARCINOGENIC AGENTS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-09 | — | — | US | disclosed |
| EP-1020446-A1 | NAPHTHALIMIDOBENZAMIDE DERIVATIVES | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |