Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4069637 | 0.90 | SIRT2 (0.47) | CYP8B1SIRT2SIRT1SIRT3CHRM4 | |
| SCHEMBL4070886 | 0.87 | CYP8B1 (0.45) | CYP8B1SIRT2SIRT1SIRT3KCNH2 | |
| SCHEMBL5905772 | 0.83 | CYP8B1 (0.49) | CYP8B1KCNH2SLC2A1 | |
| SCHEMBL4066839 | 0.82 | CYP8B1 (0.46) | CYP8B1KCNH2ACVR1 | |
| SCHEMBL4070008 | 0.81 | KCNH2 (0.44) | CYP8B1KCNH2HTR2C | |
| SCHEMBL1222880 | 0.81 | CYP8B1 (0.48) | CYP8B1 | |
| SCHEMBL4065072 | 0.79 | SIRT2 (0.39) | CYP8B1SIRT2SIRT1SIRT3CHRM4 | |
| SCHEMBL20771438 | 0.79 | NCF1 (0.54) | SIRT2SIRT1SIRT3 | |
| SCHEMBL1224565 | 0.77 | CYP8B1 (0.53) | CYP8B1KCNH2ACVR1 | |
| SCHEMBL10078646 | 0.77 | CYP8B1 (0.53) | CYP8B1KCNH2ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605938-A4 | ANTIBACTERIAL AGENTS | GLAXO GROUP LTD (GB) | 2006-11-22 | — | — | EP | disclosed |
| EP-1605938-A2 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004087145-A2 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2004-10-14 | — | — | WO | disclosed |