Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 3/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.31 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | CCR6 | P51684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739012 | 0.80 | CES1 (0.49) | CES1DNMT1CDK2ALDH1A1MAPT | |
| SCHEMBL5740387 | 0.75 | CES1 (0.38) | CES1CDK2ALDH1A1LMNAMAPT | |
| SCHEMBL5740135 | 0.72 | CES1 (0.58) | CES1DNMT1 | |
| SCHEMBL5989856 | 0.69 | MGAM (0.34) | CDK2 | |
| SCHEMBL5738059 | 0.68 | CES1 (0.65) | CES1DNMT1ALDH1A1MAPTPDE7A | |
| SCHEMBL5987497 | 0.66 | GAA (0.47) | CDK2HTR1AHTR1DHTR2CHTR7 | |
| SCHEMBL5740310 | 0.65 | CES1 (0.65) | CES1DNMT1ALDH1A1MAPTPOLB | |
| SCHEMBL5739112 | 0.64 | CES1 (0.50) | CES1ALDH1A1MAPTKMT2APOLB | |
| SCHEMBL5888016 | 0.64 | PDE3B (0.37) | CDK2HTR1AHTR1DHTR2CHTR7 | |
| SCHEMBL11042015 | 0.64 | CES1 (0.46) | CES1DNMT1CDK2HTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644362-A2 | INDOLINONE HYDRAZIDES AS C-MET INHIBITORS | Sugen, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005005378-A2 | INDOLINONE HYDRAZIDES AS C-MET INHIBITORS | SUGEN, INC. (US) | 2005-01-20 | — | — | WO | disclosed |