Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752424 | 0.80 | CES1 (0.61) | CES1ALDH1A1TGM2LRRK2CA1 | |
| SCHEMBL5329280 | 0.80 | CES1 (0.61) | CES1MAPTALDH1A1KDM4ES1PR4 | |
| SCHEMBL12856460 | 0.78 | EIF2AK2 (0.46) | MAPTGAAKDM4ELMNACA1 | |
| SCHEMBL5752202 | 0.75 | CES1 (0.34) | CES1MAPTALDH1A1KDM4ES1PR4 | |
| SCHEMBL5740595 | 0.70 | CES1 (0.61) | CES1TGM2 | |
| SCHEMBL9835981 | 0.70 | CES1 (0.61) | CES1TGM2 | |
| SCHEMBL5741222 | 0.68 | POLB (0.51) | CES1MAPTALDH1A1HTTERBB2 | |
| SCHEMBL11428923 | 0.68 | GSK3B (0.45) | MAPTALDH1A1KDM4ES1PR4HSP90AA1 | |
| SCHEMBL4163112 | 0.68 | MAPT (0.60) | CES1MAPTAGTR1ALDH1A1KDM4E | |
| SCHEMBL5988490 | 0.67 | ALDH1A1 (0.64) | MAPTSMN1; SMN2GAAALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644362-A2 | INDOLINONE HYDRAZIDES AS C-MET INHIBITORS | Sugen, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005005378-A2 | INDOLINONE HYDRAZIDES AS C-MET INHIBITORS | SUGEN, INC. (US) | 2005-01-20 | — | — | WO | disclosed |