Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.33 |
| ▸ | GPR3 | P46089 | 2/20 | 0.33 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747859 | 0.87 | CRHR1 (0.47) | CRHR1SCN9AP2RX7RUNX1CTSA | |
| SCHEMBL5752291 | 0.84 | CRHR1 (0.47) | CRHR1SCN9AP2RX7GPR3RUNX1 | |
| SCHEMBL4882797 | 0.74 | CRHR1 (0.56) | CRHR1SCN9AP2RX7 | |
| SCHEMBL14183041 | 0.73 | CRHR1 (0.56) | CRHR1SCN9AP2RX7 | |
| SCHEMBL5747855 | 0.72 | CRHR1 (0.49) | CRHR1SCN9AP2RX7RUNX1CTSA | |
| SCHEMBL6343532 | 0.71 | CRHR1 (0.55) | CRHR1SCN9AP2RX7GPR3RUNX1 | |
| SCHEMBL4626672 | 0.70 | CRHR1 (0.48) | CRHR1SCN9AGPR3RUNX1 | |
| SCHEMBL6347606 | 0.69 | CRHR1 (0.54) | CRHR1SCN9AP2RX7CTSA | |
| SCHEMBL4879256 | 0.68 | CRHR1 (0.54) | CRHR1SCN9ACTSA | |
| SCHEMBL6081426 | 0.68 | CRHR1 (0.49) | CRHR1P2RX7GPR3PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680424-A2 | HETEROARYL FUSED PYRIDINES, PYRAZINES AND PYRIMIDINES AS CRF1 RECEPTOR LIGANDS | Neurogen Corporation (US) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005023806-A2 | HETEROARYL FUSED PYRIDINES, PYRAZINES AND PYRIMIDINES AS CRF1 RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2005-03-17 | — | — | WO | disclosed |