Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | KDM5A | P29375 | 3/20 | 0.47 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.47 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28059189 | 0.91 | KDM4E (0.55) | KDM4EKDM5AKDM3AJMJD1CL3MBTL1 | |
| SCHEMBL31704503 | 0.89 | KDM4E (0.41) | KDM4EKDM5AKDM3AJMJD1CL3MBTL1 | |
| SCHEMBL1833909 | 0.85 | GSK3B (0.38) | KDM4EKDM5AKDM3AJMJD1CTSHR | |
| SCHEMBL19279418 | 0.80 | CBLB (0.37) | KDM4EL3MBTL1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL23166607 | 0.80 | PDE4D (0.43) | KDM4EKDM3AL3MBTL1ALDH1A1KDM6B | |
| SCHEMBL31706429 | 0.79 | KDM4E (0.40) | KDM4EKDM5AKDM3AJMJD1CL3MBTL1 | |
| SCHEMBL1831858 | 0.79 | ALOX5AP (0.43) | KDM4EL3MBTL1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL1118328 | 0.76 | CYP1A2 (0.53) | KDM4EL3MBTL1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL87765 | 0.74 | KDM4E (0.55) | KDM4EKDM5AKDM3AJMJD1CL3MBTL1 | |
| SCHEMBL31126262 | 0.74 | KDM4E (0.55) | KDM4EKDM5AKDM3AJMJD1CL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143195-B1 | IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 | JANSSEN PHARMACEUTICA NV (BE) | 2025-05-21 | — | — | EP | disclosed |
| US-12024524-B2 | Imidazopyridazines as modulators of IL-17 | JANSSEN PHARMACEUTICA NV (BE) | 2024-07-02 | — | — | US | disclosed |
| WO-2024067845-A1 | IMIDAZOPYRIDINE COMPOUND AS IRAK4 DEGRADATION AGENT AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2024-04-04 | — | — | WO | disclosed |
| CN-117777126-A | Imidazopyridines as IRAK4 degradants and uses thereof | 武汉人福创新药物研发中心有限公司 | 2024-03-29 | — | — | CN | disclosed |
| US-20230357254-A1 | IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-09 | — | — | US | disclosed |
| US-11702422-B2 | Imidazopyridazines as modulators of IL-17 | JANSSEN PHARMACEUTICA NV (BE) | 2023-07-18 | — | — | US | disclosed |
| US-11691979-B2 | Imidazopyridazines as modulators of IL-17 | JANSSEN PHARMACEUTICA NV (BE) | 2023-07-04 | — | — | US | disclosed |
| CN-115884810-A | Imidazopyridazines as IL-17 modulators | 詹森药业有限公司 | 2023-03-31 | — | — | CN | disclosed |
| US-20230081548-A1 | IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 | JANSSEN PHARMACEUTICA NV (BE) | 2023-03-16 | — | — | US | disclosed |
| EP-4143195-A1 | IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 | Janssen Pharmaceutica NV (BE) | 2023-03-08 | — | — | EP | disclosed |
| US-20220402922-A1 | IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 | JANSSEN RESEARCH & DEVELOPMENT, LLC | 2022-12-22 | — | — | US | disclosed |
| WO-2021222404-A1 | IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 | JANSSEN BIOTECH, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| CN-103249721-A | Arylamine Derivatives as TTX-S Blockers | RAQUALIA PHARMA INC | 2013-08-14 | — | — | CN | disclosed |
| WO-2009131815-A1 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2009-10-29 | — | — | WO | disclosed |
| EP-1694651-A1 | HERBICIDAL PYRIMIDINES | E.I.Du pont de nemours and company (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005063721-A1 | HERBICIDAL PYRIMIDINES | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2005-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11691979-B2 | Imidazopyridazines as modulators of IL-17 | IL17A, IL23R, IL15 | KDM4E 2583/4885KDM5A 1220/4885KDM3A 1535/4885 |
| US-20230357254-A1 | IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 | IL17A, IL23R, IL15 | KDM4E 2583/4885KDM5A 1220/4885KDM3A 1535/4885 |
| US-12024524-B2 | Imidazopyridazines as modulators of IL-17 | IL17A, IL23R, IL15 | KDM4E 2583/4885KDM5A 1220/4885KDM3A 1535/4885 |
| US-20230081548-A1 | IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 | IL17A, IL23R, IL15 | KDM4E 2583/4885KDM5A 1220/4885KDM3A 1535/4885 |
| US-20220402922-A1 | IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 | IL17A, IL23R, IL15 | KDM4E 2583/4885KDM5A 1220/4885KDM3A 1535/4885 |
| US-11702422-B2 | Imidazopyridazines as modulators of IL-17 | IL17A, IL23R, IL15 | KDM4E 2583/4885KDM5A 1220/4885KDM3A 1535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.