Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | KMO | O15229 | 3/20 | 0.47 |
| ▸ | KDM5A | P29375 | 4/20 | 0.44 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.44 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.40 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752341 | 0.91 | KDM4E (0.47) | KDM4EL3MBTL1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL31704503 | 0.84 | KDM4E (0.41) | KDM4EL3MBTL1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL1831858 | 0.81 | ALOX5AP (0.43) | KDM4EL3MBTL1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL28059207 | 0.78 | CYP1A2 (0.49) | KDM4EKMT2ASMN1; SMN2LMNATSHR | |
| SCHEMBL1833909 | 0.77 | GSK3B (0.38) | KDM4EKDM5AKDM3AJMJD1CTSHR | |
| SCHEMBL28071005 | 0.76 | KDM4E (0.41) | KDM4EL3MBTL1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL28059198 | 0.75 | SMN1; SMN2 (0.38) | KDM4EL3MBTL1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL25136122 | 0.75 | CD38 (0.37) | KDM4EL3MBTL1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL31706429 | 0.75 | KDM4E (0.40) | KDM4EL3MBTL1KDM5AKDM3AJMJD1C | |
| SCHEMBL3922871 | 0.73 | KDM4E (0.59) | KDM4EL3MBTL1TDP1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814043-B | Triazolopyridine derivatives as TNF active regulator | UCB生物制药私人有限公司 | 2019-05-17 | — | — | CN | disclosed |
| CN-105814049-B | Fused tricyclic imdazole derivatives as TNF active regulator | UCB生物制药私人有限公司 | 2019-03-12 | — | — | CN | disclosed |
| CN-105814041-B | Benzotriazole derivatives as TNF active regulator | UCB生物制药私人有限公司 | 2018-12-18 | — | — | CN | disclosed |
| CN-105814065-B | Imidazothiazole derivative as TNF active regulator | UCB生物制药私人有限公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-105814058-B | Triazolo-pyridazine derivatives as TNF active regulator | UCB生物制药私人有限公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-105814047-B | Fused tricyclic imdazole derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-10-19 | — | — | CN | disclosed |
| CN-105814022-B | Condensed bicyclic heteroaromatic derivative as TNF active regulators | UCB生物制药私人有限公司 | 2018-09-28 | — | — | CN | disclosed |
| CN-105814051-B | Tetrahydroimidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2018-09-25 | — | — | CN | disclosed |
| CN-105814054-B | Condensed imidazole and pyrazole derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-09-25 | — | — | CN | disclosed |
| CN-105814025-B | Tetrahydrobenzimidazderivative derivative as TNF active regulators | UCB生物制药私人有限公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-105814051-A | Tetrahydroimidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814025-A | Tetrahydrobenzimidazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814065-A | Imidazothiazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814050-A | Pyrazolopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814047-A | Fused tricyclic benzimidazoles derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814054-A | Fused imidazole and pyrazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814049-A | Fused tricyclic imidazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814043-A | Triazolopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814048-A | Fused tricyclic imidazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814052-A | Imidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |