Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5757547 | 0.88 | GRM5 (0.41) | GRM5KCNH2 | |
| SCHEMBL2895374 | 0.87 | GRM5 (0.49) | GRM5KCNH2MEN1ALDH1A1KMT2A | |
| SCHEMBL2897330 | 0.85 | MAPT (0.39) | KCNH2MEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL2891488 | 0.85 | GRM5 (0.69) | GRM5KCNH2MEN1ALDH1A1KMT2A | |
| SCHEMBL2895170 | 0.83 | GRM5 (0.45) | GRM5KCNH2MEN1ALDH1A1KMT2A | |
| SCHEMBL2895291 | 0.78 | GRM5 (0.73) | GRM5KCNH2MEN1ALDH1A1KMT2A | |
| SCHEMBL2895780 | 0.78 | GRM5 (0.73) | GRM5KCNH2MEN1ALDH1A1KMT2A | |
| SCHEMBL2895294 | 0.78 | GRM5 (0.73) | GRM5KCNH2MEN1ALDH1A1KMT2A | |
| SCHEMBL30795719 | 0.78 | GRM5 (0.67) | GRM5KCNH2 | |
| SCHEMBL1997502 | 0.78 | GRM5 (0.67) | GRM5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716125-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080356-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |