Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1382066 | 0.81 | NPC1 (0.77) | POLBNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL18361820 | 0.79 | POLB (0.65) | POLBNPC1RAB9AKDM4E | |
| SCHEMBL6949782 | 0.77 | POLB (0.62) | POLBNPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL5753442 | 0.76 | HPGD (0.56) | POLBHPGD | |
| SCHEMBL4843594 | 0.75 | POLB (0.60) | POLBNPC1RAB9A | |
| SCHEMBL4794063 | 0.75 | POLB (0.60) | POLBNPC1RAB9AKDM4E | |
| SCHEMBL31370016 | 0.71 | POLB (0.55) | POLBNPC1RAB9AALDH1A1HDAC3 | |
| SCHEMBL1092961 | 0.71 | KDM1A (0.55) | POLBNPC1RAB9AHPGDALDH1A1 | |
| Hydrochloric Acid SCHEMBL1376190 | 0.70 | POLB (0.54) | POLBNPC1RAB9AALDH1A1HDAC3 | |
| SCHEMBL28710986 | 0.70 | KMT2A (0.62) | POLBNPC1RAB9AHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1225894-B1 | FAB I INHIBITORS | AFFINIUM PHARM INC (CA) | 2006-07-05 | — | — | EP | disclosed |
| US-6730684-B1 | KEY REGULATORY POINT IN THE OVERALL SYNTHETIC PATHWAY OF BACTERIAL FATTY ACID BIOSYNTHESIS; FABI IS AN IDEAL TARGET FOR ANTIBACTERIAL INTERVENTION | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2004-05-04 | — | — | US | disclosed |