Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18361820 | 0.82 | POLB (0.65) | POLBNPC1RAB9AKDM1AMCL1 | |
| SCHEMBL4794063 | 0.81 | POLB (0.60) | POLBNPC1RAB9AKDM1AMCL1 | |
| SCHEMBL1382066 | 0.79 | NPC1 (0.77) | POLBNPC1RAB9AKDM1AMCL1 | |
| SCHEMBL25677980 | 0.78 | LMNA (0.52) | POLB | |
| SCHEMBL5752502 | 0.75 | POLB (0.73) | POLBNPC1RAB9A | |
| SCHEMBL25275650 | 0.74 | CYP19A1 (0.49) | POLBNPC1RAB9A | |
| SCHEMBL31370016 | 0.74 | POLB (0.55) | POLBNPC1RAB9AKDM1AMCL1 | |
| SCHEMBL6935651 | 0.74 | MAPT (0.66) | NPC1RAB9A | |
| SCHEMBL1104629 | 0.74 | — | — | |
| SCHEMBL1092961 | 0.74 | KDM1A (0.55) | POLBNPC1RAB9AKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973902-A2 | 3-HETEROCYCLYLACRYLAMIDE COMPOUNDS AS FABI INHIBITORS AND ANTIBACTERIAL AGENTS | Affinium Pharmaceuticals, Inc. (CA) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007067416-A2 | HETEROCYCLYLACRYLAMIDE COMPOUNDS AS FABI INHIBITORS AND ANTIBACTERIAL AGENTS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2007-06-14 | — | — | WO | disclosed |
| CN-1197860-C | FAB I inhibitors | SMITHKLINE BEECHAM CORP (CA) | 2005-04-20 | — | — | CN | disclosed |
| CN-1378542-A | Antigen binding fragment I inhibitors | SMITHKLINE BEECHAM CORP (US) | 2002-11-06 | — | — | CN | disclosed |