Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.59 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.58 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4324960 | 0.90 | CD274 (0.58) | HTR1ADRD2MAPK14ACKR3CD274 | |
| SCHEMBL8404688 | 0.87 | ACKR3 (0.57) | MAPK14ACKR3CD274MEN1KMT2A | |
| SCHEMBL8404689 | 0.86 | ACKR3 (0.56) | MAPK14ACKR3CD274MEN1KMT2A | |
| SCHEMBL15947385 | 0.85 | SMN1; SMN2 (0.59) | MAPK14ACKR3CD274MEN1KMT2A | |
| SCHEMBL31037305 | 0.85 | DRD2 (0.58) | DRD2MAPK14ACKR3CD274MEN1 | |
| SCHEMBL20458266 | 0.83 | SMN1; SMN2 (0.56) | MAPK14ACKR3CD274MEN1KMT2A | |
| SCHEMBL18763563 | 0.82 | MAPT (0.55) | HTR1ADRD2MAPK14ACKR3MEN1 | |
| SCHEMBL31330228 | 0.81 | ACKR3 (0.62) | HTR1ADRD2ACKR3 | |
| SCHEMBL5749344 | 0.80 | MEN1 (0.53) | HTR1ADRD2ACKR3MEN1KMT2A | |
| SCHEMBL19891463 | 0.79 | DRD2 (0.59) | DRD2ACKR3THRBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1099692-B1 | N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES | EISAI CO LTD (JP) | 2006-05-03 | — | — | EP | disclosed |
| EP-1099692-A1 | N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-05-16 | — | — | EP | disclosed |