Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 18/20 | 0.55 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.55 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5755136 | 0.92 | KIF11 (0.56) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4366839 | 0.89 | KIF11 (0.60) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4374528 | 0.89 | KIF11 (0.58) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5752860 | 0.88 | KIF11 (0.66) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5753733 | 0.87 | KIF11 (0.60) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5757022 | 0.87 | KIF11 (0.55) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5754666 | 0.87 | KIF11 (0.58) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5755793 | 0.86 | KIF11 (0.56) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5401219 | 0.86 | KIF11 (0.57) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5753643 | 0.85 | KIF11 (0.56) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503993-A4 | COMPOUNDS, METHODS AND COMPOSITIONS | CYTOKINETICS INC (US) | 2006-05-03 | — | — | EP | disclosed |
| EP-1503993-A2 | COMPOUNDS, METHODS AND COMPOSITIONS | Cytokinetics, Inc. (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003094839-A2 | PYRIMIDINONE COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2003-11-20 | — | — | WO | disclosed |