Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 20/20 | 1.00 |
| ▸ | CCR5 | P51681 | 2/20 | 0.65 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | GLP1R | P43220 | 1/20 | 0.58 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.58 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2994408 | 1.00 | CCR2 (1.00) | CCR2CCR5ADRB2HRH1DRD3 | |
| SCHEMBL2981544 | 0.99 | CCR2 (1.00) | CCR2CCR5ADRB2HRH1DRD3 | |
| SCHEMBL5857000 | 0.99 | CCR2 (1.00) | CCR2CCR5ADRB2HRH1DRD3 | |
| SCHEMBL2983146 | 0.99 | CCR2 (1.00) | CCR2CCR5ADRB2HRH1DRD3 | |
| SCHEMBL2985813 | 0.95 | CCR2 (0.91) | CCR2CCR5ADRB2HRH1DRD3 | |
| SCHEMBL2985811 | 0.95 | CCR2 (0.91) | CCR2CCR5ADRB2HRH1DRD3 | |
| SCHEMBL2983576 | 0.95 | CCR2 (0.90) | CCR2CCR5ADRB2HRH1DRD3 | |
| SCHEMBL2991141 | 0.95 | CCR2 (1.00) | CCR2CCR5ADRB2HRH1DRD3 | |
| SCHEMBL2989751 | 0.92 | CCR2 (0.85) | CCR2CCR5ADRB2HRH1DRD3 | |
| SCHEMBL5856526 | 0.92 | CCR2 (0.85) | CCR2CCR5ADRB2HRH1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483241-A4 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2006-12-13 | — | — | EP | disclosed |
| EP-1483241-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Company (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003075853-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-09-18 | — | — | WO | disclosed |