Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 2/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 4/20 | 0.45 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5753555 | 0.78 | FLT1 (0.80) | KMT2AMEN1FLT1KDR | |
| SCHEMBL4814640 | 0.75 | FLT1 (0.48) | GAAMAPTFLT1 | |
| SCHEMBL14267794 | 0.75 | FLT1 (0.65) | KMT2AMEN1FLT1CLK4KDR | |
| SCHEMBL5793780 | 0.75 | NPC1 (0.57) | KMT2AMEN1GAAMAPTNPC1 | |
| SCHEMBL9807640 | 0.74 | FLT1 (0.77) | KMT2AMEN1MAPTFLT1PDE5A | |
| SCHEMBL5754939 | 0.73 | KDR (0.65) | KMT2AMEN1MAPTFLT1KDR | |
| SCHEMBL1651296 | 0.73 | FLT1 (0.79) | KMT2AMEN1FLT1KDR | |
| SCHEMBL5753928 | 0.72 | KDR (0.70) | KMT2AMEN1MAPTFLT1KDR | |
| SCHEMBL7279378 | 0.70 | MEN1 (0.84) | KMT2AMEN1GAAMAPTCLK4 | |
| SCHEMBL27466738 | 0.70 | PDE5A (0.67) | KMT2AMEN1FLT1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165085-B1 | PHTHALAZINE DERIVATIVES FOR TREATING INFLAMMATORY DISEASES | NOVARTIS AG (CH) | 2006-06-14 | — | — | EP | claimed |
| US-7329660-B2 | Phthalazine derivatives for treating inflammatory diseases | NOVARTIS AG (CH) | 2008-02-12 | — | — | US | disclosed |
| US-7329660-B2 | Phthalazine derivatives for treating inflammatory diseases | NOVARTIS AG (CH) | 2008-02-12 | — | — | US | disclosed |