Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.58 |
| ▸ | EGFR | P00533 | 8/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 5/20 | 0.57 |
| ▸ | KIF5B | P33176 | 2/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.57 |
| ▸ | FLT1 | P17948 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.57 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.57 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | CLK1 | P49759 | 1/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.56 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2746962 | 0.96 | KDR (0.62) | KDREGFRMAPK14RETKIF5B | |
| SCHEMBL2746015 | 0.96 | KDR (0.62) | KDREGFRMAPK14RETKIF5B | |
| SCHEMBL2747131 | 0.86 | KDR (0.74) | KDREGFRMAPK14RETAURKA | |
| SCHEMBL2747187 | 0.82 | KDR (0.71) | KDREGFRMAPK14AURKAAURKB | |
| SCHEMBL2747392 | 0.82 | KDR (0.69) | KDREGFRMAPK14RETKIF5B | |
| SCHEMBL4549037 | 0.82 | KDR (0.69) | KDREGFRMAPK14RETKIF5B | |
| SCHEMBL2747980 | 0.81 | EGFR (0.68) | KDREGFRMAPK14FLT1LCK | |
| SCHEMBL2748014 | 0.80 | KDR (0.75) | KDREGFRFLT1AURKAAURKB | |
| SCHEMBL7117747 | 0.79 | KDR (0.71) | KDREGFRRETKIF5BFGFR1 | |
| SCHEMBL6181200 | 0.78 | EGFR (0.74) | KDREGFRRETKIF5BFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713484-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | disclosed |