Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 16/20 | 0.59 |
| ▸ | PDE7B | Q9NP56 | 3/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.35 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229305 | 0.80 | PDE7A (0.75) | PDE7APDE7B | |
| SCHEMBL5753361 | 0.80 | PDE5A (0.39) | PDE7APDE5A | |
| SCHEMBL5230233 | 0.80 | PDE7A (0.55) | PDE7APDE5APDE1APDE1BPDE1C | |
| SCHEMBL5234150 | 0.76 | PDE7A (0.71) | PDE7APDE7BPDE5A | |
| SCHEMBL1812116 | 0.76 | PDE7A (0.63) | PDE7APDE7BPDE5A | |
| SCHEMBL5231531 | 0.75 | PDE7A (0.76) | PDE7APDE7BPDE5APDE1APDE1B | |
| SCHEMBL5230067 | 0.75 | PDE7A (0.81) | PDE7APDE7B | |
| SCHEMBL5237929 | 0.74 | PDE7A (0.60) | PDE7APDE5A | |
| SCHEMBL5231143 | 0.74 | PDE7A (0.80) | PDE7APDE7B | |
| SCHEMBL5231499 | 0.74 | PDE7A (1.00) | PDE7APDE7BPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636235-A1 | PYRIDINYLPYRAZOLOPYRIMIDINONE DERIVATIVES AS PDE 7 INHIBITORS | Daiichi Asubio Pharma Co., Ltd. (JP) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004111054-A1 | PYRIDINYLPYRAZOLOPYRIMIDINONE DERIVATIVES AS PDE 7 INHIBITORS | DAIICHI ASUBIO PHARMA CO.,LTD. (JP) | 2004-12-23 | — | — | WO | disclosed |