Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | GUSB | P08236 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229312 | 0.81 | PDE7A (0.47) | PDE5AHTTKDM4EPDE7A | |
| SCHEMBL5753357 | 0.80 | PDE7A (0.59) | PDE5APDE7A | |
| SCHEMBL5230247 | 0.79 | POLB (0.44) | HPGDKDM4ENPSR1TNKSPARP1 | |
| SCHEMBL5237936 | 0.78 | POLB (0.54) | PDE5AHPGDHTTKDM4EMEN1 | |
| SCHEMBL5231538 | 0.77 | PDE5A (0.57) | PDE5AHTTKDM4EPDE7ATNKS | |
| SCHEMBL1812118 | 0.77 | PDE5A (0.41) | PDE5ARECQLHPGDHTTKDM4E | |
| SCHEMBL5234164 | 0.76 | PDE5A (0.47) | PDE5AHTTPDE7A | |
| SCHEMBL5228186 | 0.74 | PDE7A (0.49) | PDE5AHTTKDM4EPDE7AMEN1 | |
| SCHEMBL5230077 | 0.74 | PDE7A (0.49) | PDE5AHTTKDM4EPDE7APARP1 | |
| SCHEMBL5231510 | 0.74 | PDE7A (0.64) | PDE5AHTTPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636235-A1 | PYRIDINYLPYRAZOLOPYRIMIDINONE DERIVATIVES AS PDE 7 INHIBITORS | Daiichi Asubio Pharma Co., Ltd. (JP) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004111054-A1 | PYRIDINYLPYRAZOLOPYRIMIDINONE DERIVATIVES AS PDE 7 INHIBITORS | DAIICHI ASUBIO PHARMA CO.,LTD. (JP) | 2004-12-23 | — | — | WO | disclosed |