Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FOS | P01100 | 1/20 | 0.41 |
| ▸ | JUN | P05412 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1522628 | 0.83 | ALDH1A1 (0.48) | ALDH1A1SYKMAPTLMNASMN1; SMN2 | |
| SCHEMBL2225998 | 0.81 | ALDH1A1 (0.53) | ALDH1A1SYKMAPTLMNASMN1; SMN2 | |
| Fluoride SCHEMBL13517648 | 0.79 | ALDH1A1 (0.52) | ALDH1A1SYKMAPTLMNASMN1; SMN2 | |
| SCHEMBL2023250 | 0.78 | ALDH1A1 (0.57) | ALDH1A1SYKMAPTLMNASMN1; SMN2 | |
| SCHEMBL29508917 | 0.77 | ALDH1A1 (0.69) | ALDH1A1SYKMAPTLMNASMN1; SMN2 | |
| SCHEMBL28734766 | 0.77 | ALDH1A1 (0.69) | ALDH1A1SYKMAPTLMNASMN1; SMN2 | |
| SCHEMBL5658431 | 0.76 | AURKA (0.44) | ALDH1A1MAPTSMN1; SMN2POLBTDP1 | |
| SCHEMBL3127909 | 0.76 | ALDH1A1 (0.68) | ALDH1A1SYKMAPTLMNASMN1; SMN2 | |
| SCHEMBL2941673 | 0.76 | ALDH1A1 (0.68) | ALDH1A1SYKMAPTLMNASMN1; SMN2 | |
| SCHEMBL3971245 | 0.75 | ITGB1 (0.47) | ALDH1A1SYKMAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685131-A1 | HYDROXYALKYL SUBSTITUTED PYRIDO-7-PYRIMIDIN-7-ONES | F. Hoffmann-La Roche AG (CH) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047284-A1 | HYDROXYALKYL SUBSTITUTED PYRIDO-7-PYRIMIDIN-7-ONES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-26 | — | — | WO | disclosed |