⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28757967 | 1.00 | — | — | |
| SCHEMBL9286582 | 0.78 | KDM4E (0.39) | — | |
| SCHEMBL8899967 | 0.78 | — | — | |
| SCHEMBL9276885 | 0.75 | — | — | |
| SCHEMBL1263303 | 0.75 | — | — | |
| SCHEMBL12858796 | 0.73 | KDM4E (0.41) | — | |
| SCHEMBL7815667 | 0.73 | — | — | |
| SCHEMBL6661692 | 0.73 | KDM4E (0.41) | — | |
| SCHEMBL15094372 | 0.73 | — | — | |
| SCHEMBL82871 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102459166-B | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA NV | 2015-03-25 | — | — | CN | claimed |
| CN-101124199-B | 5-substituted-2-phenylamino-benzamides as MEK inhibiting substances | CHUGAI PHARMACEUTICAL CO.,LTD. (JP) | 2011-12-14 | — | — | CN | claimed |
| CN-101304978-A | Quinazoline derivatives as multiplex inhibitors and process for their preparation | HANMI PHARM IND CO LTD (KR) | 2008-11-12 | — | — | CN | claimed |
| CN-101124199-A | 5-substituted-2-phenylamino-benzamides as MEK inhibiting substances | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2008-02-13 | — | — | CN | claimed |
| CN-1910135-A | Amino alcohol derivatives and their activity as renin inhibitors | SPEEDEL EXPERIMENTA AG (CH) | 2007-02-07 | — | — | CN | claimed |
| CN-102459166-B | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA NV | 2015-03-25 | — | — | CN | disclosed |
| CN-104011028-A | N-SUBSTITUTED AMINOBENZOCYCLOHEPTENE, AMINOTETRALINE, AMINOINDANE AND PHENALKYLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | ABBVIE DEUTSCHLAND | 2014-08-27 | — | — | CN | disclosed |
| CN-103889968-A | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT GMBH & AMP | 2014-06-25 | — | — | CN | disclosed |
| CN-102083797-B | Tetrahydroisoquinolines, pharmaceutical compositions containing them and their use in therapy | ABBOTT GMBH & CO KG | 2014-06-04 | — | — | CN | disclosed |
| CN-103517898-A | Novel 3-hydroxyisothiazole 1-oxide derivatives | MOCHIDA PHARM CO LTD | 2014-01-15 | — | — | CN | disclosed |
| CN-101784533-B | 4-benzylaminoquinolines, pharmaceutical compositions containing them, and their use in therapy | ABBOTT GMBH & CO KG | 2013-08-21 | — | — | CN | disclosed |
| CN-103237788-A | Phenalkylamine derivatives, pharmaceutical compositions containing them and their use in therapy | ABBVIE DEUTSCHLAND | 2013-08-07 | — | — | CN | disclosed |
| WO-2005019172-A1 | INDOL-2-AMIDES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-03-03 | — | — | WO | disclosed |
| WO-2005018637-A1 | HETEROCYCLIC AMIDE DERIVATIVES WHICH POSSESS GLYCOGEN PHOSPHORYLASE INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2005-03-03 | — | — | WO | disclosed |
| CN-1163475-C | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors | ��ʲ | 2004-08-25 | — | — | CN | disclosed |
| CN-1160337-C | Process for preparation of vinyl pyrimidine derivant | - | 2004-08-04 | — | — | CN | disclosed |
| CN-1107059-C | Azole deriv. | YAMANOUCHI PHARMA CO LTD (JP) | 2003-04-30 | — | — | CN | disclosed |
| CN-1275566-A | Process for preparation of vinyl pyrimidine derivant | HOFFMANN LA ROCHE (CH) | 2000-12-06 | — | — | CN | disclosed |
| CN-1261877-A | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors | WARNER LAMBERT CO (US) | 2000-08-02 | — | — | CN | disclosed |
| CN-1160397-A | Azole deriv. | YAMANOUCHI PHARMA CO LTD (JP) | 1997-09-24 | — | — | CN | disclosed |