Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THPO | P40225 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3430004 | 0.80 | KDM4E (0.48) | KDM4ECA2PTGS1MMP12NFKB1 | |
| SCHEMBL12858796 | 0.79 | KDM4E (0.41) | KDM4ECA2PTGS1MMP12NFKB1 | |
| SCHEMBL7815667 | 0.79 | — | — | |
| SCHEMBL28498330 | 0.78 | KDM4E (0.46) | KDM4ECA2PTGS1MMP12NFKB1 | |
| SCHEMBL6773872 | 0.78 | CRBN (0.41) | KDM4ECA2PTGS1MMP12NFKB1 | |
| SCHEMBL82871 | 0.76 | — | — | |
| SCHEMBL4278579 | 0.74 | KDM4E (0.44) | KDM4ECA2PTGS1MMP12NFKB1 | |
| SCHEMBL31575739 | 0.74 | KDM4E (0.43) | KDM4ECA2PTGS1MMP12NFKB1 | |
| SCHEMBL10905970 | 0.73 | — | — | |
| SCHEMBL28757967 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094292-B1 | NITRIC OXIDE-BLOCKED CROSS-LINKED TETRAMERIC HEMOGLOBIN | IKOR INC (US) | 2014-07-09 | — | — | EP | claimed |
| EP-0775160-B1 | CYCLIC HEXAPEPTIDE SOMATOSTATIN ANALOGUES | DIATIDE INC (US) | 2004-08-18 | — | — | EP | claimed |
| EP-0804481-B1 | SOMATOSTATIN DERIVATIVES AND THEIR RADIOLABELLED PRODUCTS | DIATIDE INC (US) | 2003-04-16 | — | — | EP | claimed |