Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5754170 | 0.83 | KIF11 (0.43) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL4518879 | 0.82 | KIF11 (0.61) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL6358669 | 0.71 | KIF11 (1.00) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL5754455 | 0.69 | MAPT (0.43) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL4507675 | 0.68 | KIF11 (0.62) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL5108306 | 0.68 | KIF11 (0.43) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL6454042 | 0.67 | KIF11 (0.62) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL5647619 | 0.66 | TDP1 (0.55) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL27663073 | 0.65 | TDP1 (0.48) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL1882530 | 0.65 | SMN1; SMN2 (0.62) | KIF11CYP3A4MEN1KMT2AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1553931-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2006-08-30 | — | — | EP | disclosed |
| EP-1553931-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2003097053-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2003-11-27 | — | — | WO | disclosed |