Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 17/20 | 0.69 |
| ▸ | KDR | P35968 | 17/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 16/20 | 0.69 |
| ▸ | EGFR | P00533 | 12/20 | 0.69 |
| ▸ | FLT4 | P35916 | 11/20 | 0.69 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.63 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.58 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5460598 | 0.95 | KDR (0.70) | FLT1KDRFGFR1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL5445575 | 0.95 | KDR (0.72) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL5757192 | 0.94 | KDR (0.77) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL14564687 | 0.94 | KDR (0.77) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL5458850 | 0.92 | EGFR (0.78) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL5456122 | 0.92 | FLT1 (0.72) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL5755914 | 0.92 | FLT1 (0.75) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL14564686 | 0.92 | FLT1 (0.75) | FLT1KDRFGFR1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL5453620 | 0.92 | EGFR (0.76) | FLT1KDRFGFR1EGFRFLT4 | |
| SCHEMBL5460591 | 0.92 | EGFR (0.67) | FLT1KDRFGFR1EGFRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1274692-B1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2006-08-02 | — | — | EP | claimed |