Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.77 |
| ▸ | FGFR1 | P11362 | 16/20 | 0.77 |
| ▸ | FLT1 | P17948 | 16/20 | 0.77 |
| ▸ | EGFR | P00533 | 14/20 | 0.77 |
| ▸ | FLT4 | P35916 | 13/20 | 0.77 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.65 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.61 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.60 |
| ▸ | TEK | Q02763 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14564687 | 1.00 | KDR (0.77) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL5754345 | 0.94 | FLT1 (0.69) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL5755914 | 0.94 | FLT1 (0.75) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL5456122 | 0.94 | FLT1 (0.72) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL14564686 | 0.94 | FLT1 (0.75) | KDRFGFR1FLT1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL5446837 | 0.93 | FLT1 (0.71) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL5450340 | 0.93 | FLT1 (0.73) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL5465089 | 0.93 | FLT1 (0.73) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL5458850 | 0.92 | EGFR (0.78) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL5460598 | 0.92 | KDR (0.70) | KDRFGFR1FLT1EGFRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1274692-B1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2006-08-02 | — | — | EP | claimed |